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RANKL-RANK signaling pathway via Btk in osteoclast differentiation
Tec family kinases are activated by RANK and bind to scaffolding proteins (BLNK or SLP76) activated by ITAM signaling, thereby forming a complex that cooperates to activate PLCγ2. PLCγ2 in turn stimulates calcium signaling, which is required for activation of NFATc1, a transcription factor essential for osteoclast differentiation. Our data suggest that ITAM signaling may be bypassed by RANK-RANKL signaling via Btk/Tec.
