TABLE 2.
Multivariable analysis of determinants of neutrophil elastase (NE) activity in bronchiectasis
| Linear regression analysis | Logistic regression analysis to predict sputum NE >20 µg·mL−1 | Logistic regression analysis to predict sputum NE >50 µg·mL−1 | ||||
| β-estimate (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Pseudomonas aeruginosa infection | 11.5 (−6.0–29.0) | 0.2 | 2.17 (0.88–5.33) | 0.09 | 0.98 (0.28–3.38) | 0.9 |
| Sputum colour (4-point scale) | 10.4 (4.3–16.6) | 0.001 | 2.13 (1.50–3.03) | <0.0001 | 2.80 (1.70–4.62) | <0.0001 |
| MRC dyspnoea score | 6.4 (1.4–11.4) | 0.01 | 1.57 (1.18–2.09) | 0.002 | 2.43 (1.56–3.78) | <0.0001 |
| Exacerbation history (per 1 event) | 3.4 (1.4–5.3) | 0.001 | 1.07 (0.96–1.19) | 0.2 | 1.16 (1.02–1.32) | 0.03 |
| Radiological extent (per additional lobe) | 1.5 (0.1–2.9) | 0.03 | 1.12 (1.05–1.21) | 0.002 | 1.09 (0.98–1.20) | 0.1 |
| Male | 1.1 (−8.5–10.6) | 0.8 | 0.82 (0.40–1.45) | 0.5 | 0.61 (0.27–1.40) | 0.2 |
| Infection with other organisms | 0.4 (−10.6–11.4) | 0.9 | 1.23 (0.61–2.46) | 0.6 | 0.69 (0.22–2.16) | 0.5 |
| Age (per year) | 0.1 (−0.3–0.5) | 0.7 | 1.01 (0.99–1.04) | 0.4 | 1.01 (0.98–1.05) | 0.5 |
| FEV1 % pred | −0.1 (−0.3–0.1) | 0.3 | 0.98 (0.97–1.00) | 0.05 | 0.99 (0.98–1.01) | 0.5 |
MRC: Medical Research Council; FEV1: forced expiratory volume in 1 s.