. 2019 Mar 20;5(3):e01367. doi: 10.1016/j.heliyon.2019.e01367

Table 3.

Effect of base and solvent Suzuki cross coupling of 4′-bromoacetophenone (6a) with phenylboronic acid (5) under thermal conditions.

Entry	Base	Solvent/co-catalyst	Yield%^a
1	K₂CO₃	H₂O/TBAB	100 (95)
2	K₂CO₃	H₂O/TBAI	100 (90)
3	K₂CO₃	H₂O/TBATFB	100 (92)
4	K₂CO₃	H₂O/CDBAB	100 (90)
5	K₂CO₃	H₂O/CTAB	80 (78)
6	K₂CO₃	DMF	77 (75)
7	K₂CO₃	Acetonitrile	84 (83)
8	K₂CO₃	Toluene	100 (83)
9	K₂CO₃	Dioxane	100 (95)
10	K₂CO₃	Benzene	84 (80)
11	K₂CO₃	THF	88 (87)
12	TEA	H₂O/TBAB	83 (80)
13	KOH	H₂O/TBAB	90 (87)
14	KOH	DMF	100 (93)
15	KOH	Toluene	100 (91)
16	KOH	THF	100 (81)

Conversion by GC-analysis and the value between parenthesis indicates the product isolated yield%. Conditions: 4′-Bromoacetophenone/phenylboronic acid/co-catalyst (if used)/base/solvents: 1/1.2/0.6/1/10 mL, under thermal heating at 100 °C for 3 h.