Table 1.
Baseline Characteristics of the Participants.a
| Baseline RC |
p |
|||||
|---|---|---|---|---|---|---|
| Characteristics | RC2,3 (n=500)b | RC4,5 (n=589)b | RC6 (n=100)b | RC2,3 vs RC4,5 | RC2,3 vs RC6 | RC4,5 vs RC6 |
| Age, y | 69.7±10.0 [69.0, IQR 64.0, 77.0] | 70.3±10.9 [71.0, IQR 63.0, 79.0] | 68.0±13.0 (n=99) [67.0, IQR 62.0, 78.0] | 0.42 | 0.13 | 0.06 |
| Men | 333 (66.6) | 364 (61.8) | 73 (73.0) | 0.11 | 0.24 | 0.03 |
| Race | ||||||
| American Indian or Alaska native | 1 (0.2) | 4 (0.7) | 0 (0.0) | 0.38 | >0.99 | >0.99 |
| Asian | 5 (1.0) | 1 (0.2) | 1 (1.0) | 0.10 | >0.99 | 0.27 |
| Black or African American | 68 (13.6) | 89 (15.1) | 21 (21.0) | 0.49 | 0.06 | 0.14 |
| Native Hawaiian or other Pacific Islander | 1 (0.2) | 1 (0.2) | 0 (0.0) | >0.99 | >0.99 | >0.99 |
| White | 411 (82.2) | 483 (82.0) | 78 (78.0) | 0.94 | 0.33 | 0.33 |
| Multiple or not specified | 14 (2.8) | 11 (1.9) | 0 (0.0) | 0.32 | 0.14 | 0.38 |
| Hispanic or Latino ethnicity | 77 (15.4) | 63 (10.7) | 29 (29.0) | 0.02 | 0.002 | <0.001 |
| Body mass index, kg/m2 | 28.8±5.3 [28.3, IQR 25.1, 31.7] | 29.1±6.2 [28.2, IQR 24.7, 32.7] | 29.1±7.6 [27.3, IQR 23.8, 33.0] | 0.29 | 0.58 | 0.97 |
| eGFR, mL/min/1.73 m2 | 68.5±28.0 [66.9, IQR 51.0, 83.3] | 59.7±27.6 [60.7, IQR 40.4, 77.0] | 56.7±37.1 (n=99) [57.7, IQR 24.2, 80.9] | <0.001 | <0.001 | 0.34 |
| Current/former smoker | 370 (74.0) | 378 (64.2) | 61 (61.0) | <0.001 | 0.01 | 0.57 |
| Diabetes | 241 (48.2) | 407 (69.1) | 79 (79.0) | <0.001 | <0.001 | 0.04 |
| Hyperlipidemia | 454 (90.8) | 510 (86.6) | 69 (69.0) | 0.04 | <0.001 | <0.001 |
| Hypertension | 468 (93.6) | 549 (93.2) | 93 (93.0) | 0.81 | 0.82 | >0.99 |
| Kidney disease | 137 (27.4) | 232 (39.4) | 43 (43.0) | <0.001 | 0.003 | 0.51 |
| Coronary artery disease | 298 (59.6) | 375 (63.7) | 54 (54.0) | 0.17 | 0.32 | 0.07 |
| Myocardial infarction | 115 (23.0) | 155 (26.3) | 15 (15.0) | 0.23 | 0.08 | 0.02 |
| Stroke/TIA | 77 (15.4) | 92 (15.6) | 9 (9.0) | 0.93 | 0.12 | 0.09 |
| ABI, target limbs | ||||||
| ≤0.90 | 339/482 (70.3) | 284/534 (53.2) | 42/90 (46.7) | <0.001 | <0.001 | 0.26 |
| >0.90 to <1.00 | 46/482 (9.5) | 53/534 (9.9) | 4/90 (4.4) | 0.92 | 0.15 | 0.11 |
| ≥1.00 to ≤1.40 | 67/482 (13.9) | 125/534 (23.4) | 19/90 (21.1) | <0.001 | 0.11 | 0.69 |
| >1.40 or noncompressible | 30/482 (6.2) | 72/534 (13.5) | 25/90 (27.8) | <0.001 | <0.001 | 0.001 |
| Previous EVT for lower limb PAD | ||||||
| None | 236 (47.2) | 285 (48.4) | 58 (58.0) | 0.72 | 0.06 | 0.08 |
| Target limb only | 61 (12.2) | 90 (15.3) | 20 (20.0) | 0.16 | 0.05 | 0.24 |
| Contralateral limb only | 112 (22.4) | 98 (16.6) | 14 (14.0) | 0.02 | 0.06 | 0.56 |
| Both limbs | 89 (17.8) | 115 (19.5) | 8 (8.0) | 0.48 | 0.02 | 0.004 |
| Unknown | 2 (0.4) | 1 (0.2) | 0 (0.0) | 0.60 | >0.99 | >0.99 |
| Target limb procedures in the last 3 years | 0.4±1.1 [0.0, IQR 0.0, 1.0] | 0.7±1.9 [0.0, IQR 0.0, 1.0] | 0.6±1.5 [0.0, IQR 0.0, 1.0] | 0.01 | 0.01 | 0.28 |
| Previous amputations | ||||||
| None | 477 (95.4) | 489 (83.0) | 55 (55.0) | <0.001 | <0.001 | <0.001 |
| Both limbs | 4 (0.8) | 17 (2.9) | 9 (9.0) | 0.01 | <0.001 | 0.007 |
| Target limb only | 8 (1.6) | 35 (5.9) | 17 (17.0) | <0.001 | <0.001 | <0.001 |
| Highest levelc | ||||||
| Toe(s) only | 11 (91.7) | 52 (100.0) | 22 (84.6) | 0.19 | >0.99 | 0.01 |
| Foot only | 1 (8.3) | 0 (0.0) | 4 (15.4) | 0.19 | >0.99 | 0.01 |
| Contralateral limb only | 11 (2.2) | 48 (8.1) | 19 (19.0) | <0.001 | <0.001 | 0.002 |
| Highest leveld | ||||||
| Toe(s) only | 8 (53.3) | 35 (53.8) | 11 (39.3) | >0.99 | 0.52 | 0.26 |
| Foot only | 2 (13.3) | 1 (1.5) | 2 (7.1) | 0.09 | 0.60 | 0.21 |
| Below knee/above ankle | 3 (20.0) | 22 (33.8) | 10 (35.7) | 0.37 | 0.49 | >0.99 |
| Above the knee | 2 (13.3) | 7 (10.8) | 5 (17.9) | 0.67 | >0.99 | 0.50 |
Abbreviations: ABI, ankle-brachial index; eGFR, estimated glomerular filtration rate; EVT, endovascular treatment; IQR, interquartile range; PAD, peripheral artery disease; RC, Rutherford category; TIA, transient ischemic attack.
a
Continuous data are presented as the mean ± standard deviation [median, IQR Q1, Q3]; categorical data are given as the number (percentage).
b
Number of subjects unless otherwise noted.
c
Percentages are based on the number of subjects with previous target limb amputation.
d
Percentages are based on the number of subjects with previous contralateral limb amputation.