Table 5.
Analysis of Independent Predictors of 12-Month Major Adverse Events.
| Unadjusted Hazard Ratioa | p | Adjusted Hazard Ratioa | p | |
|---|---|---|---|---|
| Number of wounds on target limb at baseline (1-unit increase) | 1.38 [1.24 to 1.53] | <0.001 | 1.30 [1.14 to 1.48] | <0.001 |
| Chronic total occlusions (at least 1 vs 0) | 2.09 [1.62 to 2.69] | <0.001 | 1.89 [1.46 to 2.46] | <0.001 |
| History of previous lower limb EVT | 1.76 [1.36 to 2.27] | <0.001 | 1.77 [1.34 to 2.33] | <0.001 |
| Number of target limb procedures in the past 3 years (1-procedure increase) | 1.12 [1.08 to 1.16] | <0.001 | 1.07 [1.02 to 1.13] | 0.008 |
| Distal region treatedb | NA | <0.001 | NA | 0.008 |
| Rutherford categoryb | NA | <0.001 | NA | 0.02 |
| 2,3 vs 4,5c | 0.58 [0.44 to 0.77] | <0.001 | 0.97 [0.70 to 1.34] | 0.85 |
| 2,3 vs 6c | 0.34 [0.23 to 0.50] | <0.001 | 0.56 [0.35 to 0.90] | 0.02 |
| 4,5 vs 6c | 0.58 [0.40 to 0.84] | 0.004 | 0.58 [0.39 to 0.87] | 0.008 |
| Most severe TASC lesion typeb | NA | <0.001 | ||
| Total treated lesion length (1-cm increase) | 1.02 [1.01 to 1.03] | <0.001 | ||
| Target lesions treated (1-lesion increase) | 1.41 [1.17 to 1.69] | <0.001 | ||
| History of diabetes | 1.47 [1.13 to 1.92] | 0.004 | ||
| History of coronary artery disease | 1.46 [1.12 to 1.90] | 0.006 | 1.34 [1.02 to 1.77] | 0.03 |
| Previous major (above ankle) amputation on contralateral limb | 1.79 [1.08 to 2.96] | 0.02 | ||
| History of renal disease | 1.32 [1.02 to 1.69] | 0.03 | ||
| Smoker (current/former vs never) | 0.81 [0.63 to 1.04] | 0.10 | ||
| History of hypertension | 1.58 [0.87 to 2.90] | 0.14 | ||
| Residual stenosis <50% for all target lesions per subject | 0.78 [0.55 to 1.10] | 0.15 | ||
| History of myocardial infarction | 1.20 [0.91 to 1.59] | 0.19 | ||
| Most severe PARC calcification gradeb | NA | 0.25 | ||
| Race (non-white vs white) | 1.21 [0.90 to 1.65] | 0.21 | ||
| Age (1-year increase) | 0.99 [0.98 to 1.01] | 0.28 | ||
| Significant angiographic complication | 0.83 [0.51 to 1.34] | 0.44 | ||
| Bailout stent used | 1.20 [0.71 to 2.02] | 0.50 | ||
| History of stroke/TIA | 0.91 [0.63 to 1.31] | 0.61 | ||
| Gender | 1.04 [0.80 to 1.34] | 0.78 | ||
| BMI (1-unit increase) | 1.00 [0.98 to 1.02] | 0.87 | ||
| Ethnicity (Hispanic vs non-Hispanic) | 0.97 [0.69 to 1.39] | 0.89 | ||
| Presence of any lesion with predominantly calcified plaque | 1.00 [0.77 to 1.30] | 0.99 | ||
| History of hyperlipidemia | 1.00 [0.69 to 1.44] | 0.99 |
Abbreviations: BMI, body mass index; EVT, endovascular treatment; NA, not applicable; PARC, Peripheral Academic Research Consortium; TASC, TransAtlantic Inter-Society Consensus; TIA, transient ischemic attack.
a
Hazard ratios are presented with the 95% confidence interval in brackets.
b
Type III p value displayed.
c
Contrast statement used to estimate hazard ratio between 2 levels of Rutherford category.