Table 1.
Structural data for polymers 1–5.
| Polymer | GFLG-OtBu, % a | Jeffamine M-1000, % a | Imiquimod loading, wt % b | Mw/Mn (GPC) c | Mn (GPC), kDa c | Dh (DLS), nm d |
|---|---|---|---|---|---|---|
| 1 | 100 | 0 | 0 | 1.3 | 6.84 | – f |
| 2 | 84 | 16 | 0 | 1.9 | 5.13 | 20,1 ± 1.6 |
| 3 | 57 | 43 | 0 | 1.9 | 4.05 | 14.2 ± 0.58 |
| 4 | 47 | 53 | 0 | 1.6 | 5.58 | 14.9 ± 0.58 |
| 5 | – e | – e | 2.4 | 1.6 | 6.20 | 201.6± 17.32 |
a percentage of total substituents calculated from 1H NMR measurements; b weight percent of total conjugate calculated from UV–Vis measurements; c GPC analysis in DMF (10 mM LiBr), underestimated due to calibration with linear polystyrene standards; d peak mean from DLS size distribution by intensity in phosphate buffer (pH 7.4); e calculation not possible due to overlapping NMR-signals of side chains and imiquimod; f not soluble in water.