Table 1.

Drug carriers based on polyglycidol and polyglycidol derivatives.

Encapsulator bioactive compound	Carrier	Method of encapsulation	Reference
Proteins
BSA	Polylactide-hyperbranched polyglycidol nanoparticles	Nanoprecipitation	[68,69]
Insulin	β-cyclodextrin labeled polyglycidol nanoparticles	Coprecipitation	[70]
Insulin	β-cyclodextrin labeled polyglycidol hydrogel	Gelation	[71]
Asparaginase	Nanogels from dendritic polyglycidols with azide and -p-propargyloxy-benzacetale	Inverse nanoprecipitation	[72]
transglutaminase 1	Poly(N-isopropylacrylamide)-polyglycerol-based nanogels	Nanogel swelling in protein solution	[73]
Nucleic acids
DNA	Quarternized a poly(glycidol-co-ethylene oxide)	Nanoprecipitation	[74]
pDNA	Quarternized branched poly(glycidol-co-2,3-epoxypropyldiethyl-amine) and DNA polyplexes	Incubation of polymer and nucleic acid solution	[75]
siRNA	Polyplexes of corona aminated hyperbranched polyglycidol and siRNA	Incubation of polymer and nucleic acid solution	[76]
siRNA	Polyplexes of hyperbranched polyglycidol modified with glycine and siRNA	Incubation of polymer and nucleic acid solution	[77]
siRNA	Polyplexes of amphiphilic copolymer containing hyperbranched polyglycidol end-capped with amines and siRNA	Incubation of polymer and nucleic acid solution	[78]
pDNA	Polyplexes of adamantane-modified hyperbranched polyglycerol end-capped with cationic β-cyclodextrin and pDNA	Incubation of polymer and nucleic acid solution	[79]
pDNA	Polyplexes of polyglycidol-pluronic-poly-glycidol with 2-(N,N-dimethylaminomethyl)-5-aminomethyl phenylboronic acid groups and pDNA	Incubation of polymer and nucleic acid solution	[80]
pDNA	Polyplexes of poly(ethylene oxide)-(branched polyglycidol) with endgroups capped with tris(2-aminoethyl)amine)	Incubation of polymer and nucleic acid solution	[81]
pDNA	nanodiamond particles with immobilized polyglycidol modified with grafted poly(arg-co-lys-co-his)	Incubation of nanocarrier and nucleic acid solution	[82]
pDNA and doxorubicin hydrochloride	Vesicles composed of cyclodextrin labeled with branched polyglycidol end-capped with tris(2-aminoethyl)amine) and bearing aliphatic chains	Nanoprecipitation	[83]
DNA Lamin A/C) and 5′-CTGGACTTCCAGAAGAACATT-3−	Polyplexes of hyperbranched polyglycidol modified by addition of oligoamines via the photo-cleavable linkages	Incubation of polymer and nucleic acid solution	[84]
Anticancer drugs
Doxorubicin	Hyperbranched polyglycidol	Covalent immobilization via the enzymatically cleavable linkage	[85]
Doxorubicin	Hyperbranched polyglycidol with grafted poly(ethylene oxide)	Covalent immobilization via the enzymatically cleavable linkage	[86]
Doxorubicin	Poly(ethylene oxide)-[hyperbranched polyglycidol]	Covalent immobilization via pH sensitive hydrazone linkage	[87]
Doxorubicin	Hyperbranched polyglycidol with grafted poly(ethylene oxide) and targeting antibodies agains epidermal growth factor	Covalent immobilization via pH sensitive hydrazone linkage	[88]
Doxorubicin, indodicarbocyanine dye	Hyperbranched polyglycidol	Covalent immobilization of drug and dye via cleavable linkage. Monitoring of drug release by fluorescence	[89]
Doxorubicin	Nanodiamond particles with grafted hyperbranched polyglycidol end-capped with RGD tripeptide	Covalent immobilization via pH sensitive hydrazone linkage	[90]
Cisplatin	Hyperbranched polyglycidol modified with succinic anhydride	Covalent immobilization via carboxyl groups	[91]
Cisplatin	Nanodiamond particles with grafted hyperbranched polyglycidol end-capped with RGD tripeptide and COOH groups	Covalent immobilization via carboxyl groups	[92]
Methotrexate	Fe3O4 nanoparticles with immobilized hyperbranched polyglycidol	Covalent immobilization via pH sensitive hydrazone linkage	[93]
Paclitaxel	Hyperbranched polyglycidol with sulfate and amine end groups	Covalent immobilization via cleavable ester linkage	[94]
Paclitaxel	Hyperbranched polyglycidol with attached poly(ethylene oxide) and alkyl chains	Solubilization of hydrophobic drug	[95,96]
Paclitaxel	Polymeric micelles of hyperbranched polyglycidol labeled with β-cyclodextrin	Nanoprecipitation	[97]
Docetaxel	Hyperbranched polyglycidol with attached poly(ethylene oxide) and alkyl chains	Solubilization of hydrophobic drug	[96]
Docetaxel	Hyperbranched polyglycidol with attached alkyl chains	Nanoprecipitation	[98]
Sagopilone	Hyperbranched polyglycidol with attached alkyl chains	Entrapment during micellization	[99]
Miscellaneous
Nimodipine	Hyperbranched polyglycidol with biphenyl groups in the core	Solubilization of hydrophobic drug	[100]
Quercetin	Polylactide-(hyperbranched polyglycidol)	Nanoprecipitation	[101]
Endomorphins	Hyperbrached polyglycidol modified by addition of poly(lactide-co-glycolide) chains	Water-in oil-in water double emulsification	[102]