Table 4.
ROS, enzyme and multi-stimuli responsive polymer preparations used for gene delivery.
| Polymer used | Type of trigger | Type of linkage/sensitive moieties | Gene used | Ref. |
|---|---|---|---|---|
| Poly-(1,4-phenyleneacetone dimethylene thioketal) | ROS | Thioketal | siRNA | [146] |
| mPEG113-b-CP5K-b-PDMAEMA42-b-P(DMAEMA22-co-BMA40-co-PAA24) (PPDDBP) | ROS and pH | CP5K peptide linker, PAA | pDNA | [147] |
| PEG2000-peptidyl lipids | Enzyme | Elastase or MMP-2-mediated digestion | pDNA | [148] |
| PEG-pp-PEI-PE | Enzyme | MMP-2-mediated digestion | siRNA | [149] |
| PEG-PAsp(AED)-PDPA | pH and redox potential | Di-sulfide linkage | siRNA | [150] |