Table 1.

Physicochemical properties of model drugs.

Model drug	Molecular structure	Solubility in water	Log P	pKa	Melting point
LID		Water Soluble (50 mg/mL) [9]	Less than or equal to zero [10]	7.86 [11]	75–79 °C [9]
DIC		Water Soluble (20 mg/mL) a	0.70 [12]	4.15 [13]	288–290 °C [14]
IBU		Slightly Soluble (21 mg/L at 25 °C) [15]	3.97 [15]	4.91 [15]	75–77.5 °C [15]

^a Experimental value.