Table 3.
Effect of drug physicochemical properties on the dependent variables involved in the swelling studies of in situ loaded PEO hydrogel films. Values in brackets indicate the standard deviation from the reported mean. (n = 4, * Significantly different from unmedicated hydrogel; p < 0.05).
| PEO (Mw = 1000,000 g/mol) hydrogel cross-linked with 5% w/w PETRA | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Independent parameter | Unmedicated | LID (% w/w) | DIC (% w/w) | ||||||
| 1.12 | 3.57 | 6.30 | 9.93 | 3.17 | 8.37 | 13.12 | 20.26 | ||
| Dependent parameters | |||||||||
| Thickness of dry film (µm) | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 |
| Thickness of swollen film (µm) | 320 | 320 | 320 | 340 | 345 | 355 | 380 | 420 | 485 |
| Equilibrium Swelling (%) | 199.84 (±9.24) |
203.37 (±2.34) |
255.11 * (±9.22) |
288.55 * (±6.46) |
306.14 * (±8.79) |
399.48 * (±9.94) |
514.71 * (±19.43) |
583.15 * (±41.51) |
736.07 * (±84.93) |
| Gel Fraction (%) | 85.84 (±1.65) |
82.03 * (±0.31) |
81.51 * (±0.98) |
80.52 * (±1.01) |
79.54 * (±0.42) |
76.34 * (±1.72) |
71.24 * (±4.56) |
62.16 * (±5.81) |
57.26 * (±7.34) |
| Average Molecular Weight Between Cross-links, (g/mol) | 734.48 (±62.36) | 756.54 (±57.15) | 1187.03 * (±84.17) | 1508.77 * (±68.17) | 1710.96 * (±136.21) | 2921.48 * (±179.43) | 4856.94 * (±363.97) | 6243.55* (±886.04) | 9927.18 * (±2424.43) |
| Cross-link Density, × 10−4 (mol/cm3) | 16.45 (±1.56) |
15.87 (±0.36) | 10.16 * (±0.77) | 7.92 * (±0.36) | 7.05 * (±0.50) |
4.12 * (±0.26) |
2.48 * (±0.19) |
1.96 * (±0.27) |
1.26 * (±0.22) |
| Mesh Size, ξ (nm) | 2.73 (±0.08) |
2.76 (±0.04) | 3.65 * (±0.06) | 4.26 * (±0.12) | 4.60 * (±0.13) |
6.45 * (±0.25) |
8.93 * (±0.43) |
10.49 * (±0.96) | 14.14 * (±2.12) |