Table 4.

Effect of loading method and drug physicochemical properties on the melting temperatures (T_m) and degree of crystallinity of hydrogel polymeric film. T_m and corresponding $\Delta H_f$ values were obtained from second heating (cycle 3). Values in brackets indicate the standard deviation from reported mean (n = 3; * Significantly different from corresponding unmedicated hydrogels Significantly different within groups; p < 0.05).

Sample	Drug concentration (%w/w)	Tm (Cycle 3) (°C)	$\Delta {\mathit{H}}_{\mathit{f}}$ (J/g)	XC (%)
Unmedicated	-	63.1 (±0.9)	103.7 (±3.4)	52.7 (±1.7)
Unmedicated (350 °C)	-	57.0 (±0.5)	145.5 (±1.9)	73.9 (±0.9)
Unmedicated (EtOH)	-	61.9 (±1.3)	97.7 (±0.9)	49.6 (±0.5)
Post-loaded LID	1.18	62.3 (±0.5)	103.0 (±4.5)	52.3 (±2.3)
	3.64	64.4 (±0.4)	95.2 (±3.3) *	48.4 (±1.7) *
	6.31	63.9 (±0.5)	90.3 (±1.4) *	45.9 (±0.7) *
	9.75	62.9 (±0.9)	87.3 (±2.1) *	44.4 (±1.1) *
Post-loaded DIC	3.28	58.5 (±0.2)	136.6 (±2.4) *	69.4 (±1.2) *
	8.39	56.4 (±0.2) *	115.8 (±1.9) *	58.8 (±0.9) *
	13.62	55.6 (±0.2) *	112.1 (±4.0) *	56.9 (±2.1) *
	20.68	54.3 (±0.3) *	105.9 (±2.3) *	53.8 (±1.2) *
Post-loaded IBU	15.44	60.2 (±0.2)	75.6 (±2.7) *	38.4 (±1.4) *
	31.01	55.3 (±0.1) *	61.3 (±3.0) *	31.1 (±1.5) *
	45.48	51.3 (±2.1) *	49.8 (±5.0) *	25.3 (±2.5) *
	59.09	51.0 (±5.1) *	46.7 (±5.9) *	23.8 (±3.0) *
In situ Loaded LID	1.12	64.6 (±0.8)	100.1 (±3.7)	50.9 (±1.9)
	3.57	64.6 (±0.5)	102.3 (±3.8)	52.3 (±1.9)
	6.3	64.5 (±0.2)	103.2 (±0.3)	52.4 (±0.1)
	9.93	64.2 (±0.5)	98.9 (±1.1)	50.2 (±0.6)
In situ Loaded DIC	3.17	57.0 (±0.5)	139.0 (±7.8)	70.6(±3.9)
	8.37	56.0 (±1.8)	133.7 (±5.4) *	68.0 (±2.7) *
	13.12	55.4 (±0.5) *	119.0 (±0.2) *	60.5 (±1.0) *
	20.26	52.6 (±0.4) *	99.8 (±2.6) *	50.7 (±1.3) *