Table 9.

Effect of loading method and drug physicochemical properties on the release kinetics.

Formulation	Drug concentration (% w/w)	Zero order		First order		Higuchi model		Korsmeyer-peppas model
		R2	K0	R2	K1	R2	K2	R2	K3	n
Post-loaded LID	9.75	0.961	13.016	0.962	1.511	0.961	13.016	0.999	1.536	0.788
Post-loaded DIC	20.68	0.958	15.349	0.966	1.595	0.958	15.349	0.995	1.621	0.733
Post-loaded IBU	59.09	0.993	3.343	0.986	0.575	0.995	4.571	0.989	0.006	0.015
In situ Loaded LID	9.93	0.994	8.099	0.987	0.744	0.994	8.099	0.970	0.908	0.786
In situ Loaded DIC	20.26	0.956	6.3498	0.982	1.398	0.962	6.774	0.981	1.403	1.811