Table 1.

Copy Number Alteration Determination by MSK-IMPACT

Variable	9p24.1 (JAK2/PD-L1/PD-L2) amp (non-TNBC)	9p24.1 (JAK2/PD-L1/PD-L2) amp (TNBC)	9p24.1 (JAK2/PD-L1/PD-L2) del (non-TNBC)	9p24.1 (JAK2/PD-L1/PD-L2) del (TNBC)
Coverage, mean (range)	842.6× (309×–2610×)	754.9× (405×–1135×)	654.8× (227×–994×)	852.3× (488×–1300×)
Tumor purity, histology, mean (range)	48% (20%–70%)	43% (20%–70%)	56.4% (40%–80%)	53.3% (30%–80%)
Minimum copy number gain	+1.6 FC	+2.0 FC	NA	NA
Minimum copy number loss	NA	NA	−1.8 FC	−1.8 FC

Amp, amplification; Del, deletion; FC, fold change; MSK-IMPACT, Memorial Sloan Kettering-Integrated Mutation Profiling Of Actionable Cancer Targets; NA, not applicable; TNBC, triple-negative breast cancer.