Table 5.
Values of the haematological and biochemical parameters in mice treated i.p. with hydrogels single dose treatment at 14 and 7 (GT columns) days after the experiment.
| Group | G1 | G1T | G2 | G2T | G3 | G3T | G4 | G4T |
|---|---|---|---|---|---|---|---|---|
| n | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| WBC (K/μL) | 5.60 ± 0.11 | 5.50 ± 0.03 | 5.56 ± 0.13 | 5.60 ± 0.06 | 5.65 ± 0.10 | 5.61 ± 0.12 | 5.62 ± 0.15 | 5.55 ± 0.09 |
| N (%) | 26.93 ± 0.82 | 26.78 ± 1.08 | 27.02 ± 0.61 | 27.05 ± 0.44 | 27.20 ± 0.75 | 26.03 ± 1.82 | 26.54 ± 1.56 | 26.20 ± 1.71 |
| L (%) | 64.20 ± 0.88 | 65.48 ± 1.32 | 65.23 ± 1.14 | 63.12 ± 1.41 | 64.96 ± 1.10 | 64.81 ± 1.48 | 64.41 ± 1.20 | 66.81 ± 1.54 |
| M (%) | 6.13 ± 0.51 | 6.21 ± 0.92 | 6.48 ± 0.21 | 6.46 ± 0.56 | 5.96 ± 1.64 | 6.29 ± 0.17 | 6.28 ± 0.71 | 6.51 ± 0.49 |
| E (%) | 0.72 ± 0.47 | 0.89 ± 0.52 | 0.71 ± 0.51 | 0.86 ± 0.26 | 0.91 ± 0.23 | 0.72 ± 0.33 | 0.94 ± 0.14 | 0.87 ± 0.26 |
| B (%) | 0.85 ± 0.35 | 0.93 ± 0.42 | 0.72 ± 0.25 | 0.83 ± 0.25 | 0.96 ± 0.43 | 0.86 ± 0.41 | 0.88 ± 0.36 | 0.91 ± 0.31 |
| RBC (mil/μL) | 8.66 ± 0.06 | 8.52 ± 0.09 | 8.23 ± 0.25 | 7.98 ± 0.82 | 7.92 ± 0.68 | 8.31 ± 0.26 | 8.19 ± 0.18 | 8.69 ± 0.08 |
| Hb (g/dL) | 13.10 ± 0.09 | 13.40 ± 0.17 | 12.60 ± 0.37 | 12.80 ± 0.87 | 13.00 ± 0.15 | 13.90 ± 0.89 | 12.60 ± 0.21 | 13.80 ± 0.76 |
| PCV (%) | 41.60 ± 0.06 | 43.00 ± 0.84 | 40.40 ± 0.15 | 41.00 ± 0.28 | 41.60 ± 0.21 | 43.30 ± 0.71 | 40.00 ± 0.36 | 44.90 ± 1.21 |
| PLT (K/μL) | 828 ± 19 | 955 ± 39 | 953 ± 30 | 969 ± 54 | 828 ± 11 | 964 ± 47 | 922 ± 45 | 888 ± 31 |
| ASAT (U/L) | 136 ± 28 | 142 ± 27 | 140 ± 21 | 138 ± 19 | 135 ± 13 | 141 ± 18 | 138 ± 21 | 140 ± 31 |
| ALAT (U/L) | 64 ± 3 | 64 ± 8 | 67 ± 2 | 74 ± 2 | 68 ± 5 | 72 ± 5 | 69 ± 4 | 64 ± 7 |
| urea (mg/dL) | 47 ± 6 | 50 ± 4 | 53 ± 4 | 49 ± 7 | 50 ± 5 | 49 ± 6 | 54 ± 2 | 54 ± 4 |
| CREAT (mg/dL) | 0.42 ± 0.16 | 0.34 ± 0.22 | 0.43 ± 0.13 | 0.35 ± 0.26 | 0.45 ± 0.10 | 0.35 ± 0.19 | 0.46 ± 0.11 | 0.42 ± 0.09 |
| UA (mg/dL) | 2.40 ± 0.52 | 2.64 ± 0.72 | 2.24 ± 0.46 | 2.16 ± 0.28 | 2.31 ± 0.38 | 2.23 ± 0.18 | 2.53 ± 0.41 | 2.37 ± 0.19 |
| CHOL (mg/dL) | 89 ± 3 | 91 ± 2 | 87 ± 3 | 86 ± 4 | 88 ± 4 | 87 ± 4 | 92 ± 2 | 88 ± 5 |
| PROT (g/dL) | 7.03 ± 0.18 | 6.84 ± 0.41 | 7.03 ± 0.11 | 6.58 ± 0.44 | 6.48 ± 0.78 | 6.21 ± 0.98 | 6.82 ± 0.53 | 6.49 ± 0.51 |
n = number of mice per group, WBC = white blood cell count, N = neutrophils, L = lymphocytes, M = monocytes, E = eosinophils, B = basophils, RBC = red blood cell count, Hb = haemoglobin, PCV = packed cell volume (haematocrit), PLT = platelet count, ASAT = aspartate aminotransferase, ALAT = alanine aminotransferase, CREAT = serum creatinine, UA = uric acid, CHOL = total cholesterol, PROT = total proteins.