Table 7.
In vitro drug release characteristics, including kinetic parameters (nr and kr) of HA/PVA hydrogels at different pHs.
| Samples name | pH | Maximum amount released (%) | teqr (min) | t1/2r (min) | nr | R2nr | Kr (min)−n | R2kr |
|---|---|---|---|---|---|---|---|---|
| HAPVA2cy-MTX | 2 | 37.4 | 390 | 27 | 0.073 | 0.97 | 0.72 | 0.99 |
| HAPVA3cy-MTX | 2 | 36.5 | 180 | 29 | 0.097 | 0.99 | 0.75 | 0.99 |
| HAPVA2cy-MTX | 3.5 | 36.3 | 330 | 24.4 | 0.079 | 0.95 | 0.68 | 0.99 |
| HAPVA3cy-MTX | 3.5 | 35.3 | 240 | 26.3 | 0.110 | 0.97 | 0.67 | 0.99 |
| HAPVA2cy-MTX | 5.5 | 48.2 | 450 | 35 | 0.087 | 0.97 | 0.59 | 0.99 |
| HAPVA3cy-MTX | 5.5 | 44.5 | 250 | 35 | 0.098 | 0.99 | 0.62 | 0.99 |
| HAPVA2cy-MTX | 7.4 | 53.4 | 600 | 46 | 0.044 | 0.99 | 0.74 | 0.99 |
| HAPVA3cy-MTX | 7.4 | 51.5 | 480 | 44 | 0.054 | 0.98 | 0.78 | 0.99 |
nr—diffusional exponent that characterizes the drug release mechanism; kr—release kinetic constant; R2nr/R2kr—correlation coefficient; t1/2r—time for the drug concentration to decrease to one half of its original value; teqr—time at the maximum drug released.