Table 3.
Examples of polymer-graphene electrospun scaffolds for tissue engineering.
Polymers (and additives) | Solvents | Nanocarbons | Filler loading (wt %) | Structure | Main improvements | Target tissue | Refs |
---|---|---|---|---|---|---|---|
CS/GEL/HA | AA/H2O | GO; RGO | 2% | Random | Bioactivity, antibacterial and mechanical properties | Bone | [155] |
CS/PEO/BC | AA/H2O | GO | 0–2 | Random D = 145–254 nm | Mechanical properties | Skin | [153] |
CS/PVP/PEO | AA/H2O | GO | 0–2 | Random, D = 80–200 nm | Mechanical properties, bioactivity | Skin/bone | [152] |
GEL | DMSO | GO-g-[P(HEMA-g-CL)] | 2–3 | Random, D = 100–200 nm | Mechanical and electrical properties, wettability | Not specified | [151] |
PAN | DMF | GO; RGO | N/A | Random | Mechanical, electrical properties | Not specified | [157] |
PCL | CHCl3 | GO | N/A | Random, D = N/A | Mechanical, electrical, cell signaling | Skeletal muscle | [158] |
PCL | CHCl3 | GO | 0.3–2 | Random, D = 0.1–8 μm | Mechanical, electrical properties, bioactivity | Muscle | [159] |
PCL | DMF | GO | 0.3–0.5 | Random; D = 1–3 μm | Cell differentiation | Nerve/cartilage | [8] |
PCL | DMF | GO | 0.5–2 | Random, D = 0.2–2.5 μm | Mechanical properties, bioactivity, biodegradability | Bone | [160] |
PCL | DCM/EtOH 4:1 | GO; GO-g-PEG | 0.25–2 | Random, D = 200–1000 nm | Mechanical, wettability, cell adhesion | Osteochondral | [7] |
PCL | AA | GO; RGO | 0–1 | Aligned, D = 100–400 nm | Mechanical properties | Not specified | [161] |
PLA | CHCl3/DMF | GO; GO-g-PEG | 2 | Random, D = 500–1000 nm | Mechanical properties | Osteochondral | [28] |
PLA/HA | DCM/DMF | GO | 1–3 | D = 412–516 nm | Mechanical, bioactivity | Bone | [162] |
PLA/PU 4:1 | DMF/DCM 2:3 | GO | 5 | Random, D ~ 1 μm | Biocompatibility, antimicrobial properties | Cartilage | [163] |
PLGA | THF/DMF | GO | 1 | D = 783–1461 nm | Wettability, bioactivity | Bone | [164] |
PLGA/Col | HFIP | GO | 4 | Random, D = 100–950 nm | Cell proliferation, mechanical properties | Bone/muscle | [124] |
PLGA/RGD | HFIP | GO | N/A | Random, D = 200–1440 nm | myogenic differentiation | Bone/muscle | [123] |
PLGA/SF | HFIP | GO | 1 | Random, D = 130–280 nm | Mechanical, wettability, cell differentiation | Bone | [165] |
PLLA | HFIP | GO | N/A | Aligned; D = 680 nm | Cell differentiation and growth | Nerve | [166] |
PU | DMF | GO | 0.5-2 | D = 290–400 nm | Mechanical properties, bioactivity | Osteochondral | [167] |
PVA | H2O | GNS | 1%–7% | Random, D = 200-800 nm | Electrical properties | Cartilage | [168] |
PVA | H2O | GO | 0-5 | Random, D < 1 μm | Mechanical properties, bioactivity | Bone | [169] |
PVA/CS | AA/H2O | GO | 0.05–0.6 | D = 123–200 nm | Mechanical properties | Skin | [156] |
PVC; FN | THF/DMF (4:1) | GO; RGO | N/A | N/A | Mechanical, electrical properties, bioactivity | Nerve | [170] |
SF | H2O | GO; RGO | N/A | D = 3.9–5.2 μm | Electrical properties | Nerve | [154] |
N/A: Data not available; D: Diamater; The other acronyms are available in the acronym list.