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In Vitro Cytotoxicity and FAP Activation of the N-2′ Derived Peptidyl Emetine Analogs and Prodrugs
| Compounds | PC3 [IC50 (nM)] |
LNCaP [IC50 (nM)] |
% hydrolysis to emetine |
|---|---|---|---|
| Emetine | 29.43± 3.2 | 31.6± 2.4 | NA |
| 1 | 9820±87 | 7653± 81 | 0.0 |
| 2 | 8192±19 | 6271± 12 | 0.0 |
| 3 | >10,000 | >10,000 | 0.0 |
| 4 | 4712±12 | 3201± 10 | 0.0 |
| 5 | 8230± 51 | 6281± 98 | NA |
| 6 | >10,000 | >10,000 | NA |
| 7 | 9120± 91.8 | 7340± 88 | 0.0 |
| 8 | 8815± 161 | 9811± 98 | 0.0 |
