Table 2.
Complete Results of Polygenic Risk Score Dissection Analysis
| P-value | Effect | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disorder | Subphenotype | N | Cases | Controls | BPSCZ | BP | SCZ | BAS | BPSCZ | BP | SCZ | BAS | ||
| BD | psychosis | 8131 | 4632 | 3499 | 7.9E-13 | 5.3E-05 | 1.2E-10 | 5.8E-01 | 7.17 | 4.04 | 6.45 | 0.55 | ||
| suicide ideation | 5399 | 3801 | 1598 | 7.8E-01 | 1.8E-01 | 8.7E-01 | 1.7E-01 | −0.28 | −1.35 | 0.16 | 1.37 | |||
| family history | 4971 | 2730 | 2241 | 6.1E-02 | 2.8E-01 | 2.6E-01 | 6.9E-01 | 1.87 | 1.09 | 1.13 | −0.39 | |||
| irritable mania | 4230 | 2401 | 1829 | 3.8E-01 | 4.1E-01 | 7.1E-01 | 1.0E-01 | 0.88 | 0.83 | 0.38 | −1.63 | |||
| rapid cycling | 5214 | 1744 | 3470 | 7.9E-03 | 5.1E-02 | 5.5E-02 | 3.1E-01 | −2.66 | −1.95 | −1.92 | 1.01 | |||
| alcohol substance dependence | 5440 | 1494 | 3946 | 4.5E-01 | 2.1E-01 | 2.8E-02 | 1.7E-01 | −0.75 | 1.25 | −2.20 | −1.36 | |||
| panic disorder | 4647 | 863 | 3784 | 2.8E-01 | 1.8E-01 | 6.3E-01 | 4.0E-01 | −1.07 | −1.33 | −0.49 | 0.83 | |||
| panic attacks | 3976 | 851 | 3125 | 1.3E-01 | 1.1E-02 | 9.0E-01 | 4.7E-02 | −1.50 | −2.56 | 0.13 | 1.98 | |||
| mixed states | 4044 | 826 | 3218 | 1.0E-01 | 4.2E-02 | 4.8E-01 | 6.0E-02 | −1.64 | −2.03 | −0.71 | 1.88 | |||
| unipolar mania | 4863 | 461 | 4402 | 2.4E-02 | 2.5E-01 | 4.3E-01 | 6.1E-01 | 2.26 | 1.14 | 0.78 | 0.51 | |||
| comorbid migraine | 2652 | 410 | 2242 | 1.3E-02 | 1.2E-03 | 7.2E-01 | 4.4E-01 | −2.48 | −3.23 | −0.36 | 0.77 | |||
| comorbid OCD | 4215 | 386 | 3829 | 9.7E-01 | 1.0E-01 | 3.1E-01 | 1.9E-01 | −0.04 | −1.64 | 1.02 | 1.30 | |||
| comorbid eating disorder | 3839 | 331 | 3508 | 2.1E-01 | 6.7E-02 | 8.1E-01 | 6.3E-01 | −1.25 | −1.83 | 0.24 | 0.48 | |||
| suicide attempt | 6308 | 2412 | 3896 | 1.2E-01 | 1.4E-02 | 5.3E-01 | 2.8E-01 | −1.54 | −2.45 | −0.63 | 1.09 | |||
| age of onset | 8610 | 6.2E-03 | 9.3E-01 | 7.9E-04 | 6.2E-01 | −2.74 | 0.09 | −3.36 | −0.50 | |||||
| age at interview | 8062 | 5.9E-01 | 1.9E-02 | 5.7E-01 | 4.4E-01 | 0.54 | 2.35 | −0.57 | −0.78 | |||||
| episodes mixed mania | 6587 | 6.3E-01 | 2.6E-01 | 5.6E-01 | 3.2E-01 | −0.48 | 1.13 | −0.58 | −1.00 | |||||
| episodes depressive | 6252 | 7.4E-03 | 7.6E-01 | 1.6E-02 | 9.6E-01 | −2.68 | −0.31 | −2.42 | −0.05 | |||||
| episodes total | 5958 | 1.3E-01 | 8.9E-01 | 2.6E-01 | 3.9E-01 | −1.51 | −0.14 | −1.13 | −0.87 | |||||
| year of birth | 5317 | 1.7E-01 | 1.3E-01 | 4.0E-02 | 3.6E-02 | 1.39 | −1.53 | 2.05 | 2.10 | |||||
| number of suicide attempts | 5015 | 6.2E-02 | 1.9E-01 | 2.7E-01 | 4.9E-01 | −1.87 | −1.30 | −1.10 | −0.69 | |||||
| number of hospitalizations | 3944 | 4.2E-04 | 1.5E-02 | 2.5E-02 | 7.4E-01 | 3.53 | 2.43 | 2.25 | −0.33 | |||||
| age of onset depression | 3467 | 2.3E-01 | 4.0E-01 | 7.2E-02 | 2.2E-01 | −1.19 | 0.83 | −1.80 | 1.24 | |||||
| age of onset mania | 3395 | 2.5E-01 | 6.1E-02 | 1.9E-02 | 2.2E-01 | −1.14 | 1.87 | −2.35 | −1.23 | |||||
| SCZ | Manic | 6908 | 2.4E-02 | 2.0E-05 | 9.9E-01 | 3.5E-02 | 2.26 | 4.26 | 0.01 | −2.10 | ||||
| Depressive | 6907 | 9.0E-01 | 5.7E-01 | 7.4E-01 | 1.8E-01 | 0.13 | −0.57 | −0.33 | −1.36 | |||||
| Negative | 8355 | 1.5E-05 | 2.9E-01 | 3.6E-06 | 2.1E-02 | 4.33 | 1.06 | 4.64 | 2.31 | |||||
| Positive | 8259 | 4.1E-01 | 9.9E-01 | 3.7E-01 | 5.1E-01 | 0.82 | 0.01 | 0.89 | 0.65 | |||||
Polygenic scoring results of all four GWAS phenotypes (BD+SCZ vs controls, BD vs controls, SCZ vs controls and SCZ vs BD) and 24 subphenotypes from BD and 4 subphenotypes from SCZ, rows without case/control counts are quantitative measures. Significance and effects are from regression analysis of subphenotype on PRS including principal components of ancestry and site as covariates. Effect is the regression estimate divided by the standard error.