Table 9.
Effects of Different Dosage of Aidi Injection on Chemotherapy-Related Toxicity and Performance Status.
| Non-Aidi Group |
Aidi Group |
||
|---|---|---|---|
| (N = 1600), n (%) | Less Than Conventional Dosage (n = 183), n (%) | Conventional Dosage (n = 1417), n (%) | |
| Toxicity | |||
| AST elevation | 213 (13.3) | 27 (9.6) | 127 (8.9)a,b |
| ALT elevation | 276 (17.3) | 31 (16.9) | 152 (10.7)a,b |
| CR elevation | 79 (4.9) | 8 (4.4) | 36 (2.7)b |
| Nausea, vomiting | 756 (47.2) | 67 (36.6) | 527 (37.0)a,b |
| Diarrhea | 167 (10.4) | 18 (8.2) | 76 (5.4)a,b |
| Constipation | 120 (7.5) | 16 (8.7) | 77 (5.3)a |
| Allergy | 96 (6.0) | 8 (4.4) | 56 (4.0)a |
| Leucopenia | 490 (30.6) | 41 (22.4)a | 338 (23.9)a |
| Neutropenia | 393 (24.6) | 43 (23.4) | 305 (21.5)a |
| Thrombocytopenia | 235 (14.7) | 18 (9.8) | 134 (9.4)a |
| Performance status | |||
| Deterioration | 59 (3.7) | 4, (2.2) | 2 (0.2)a,b |
| Stabilization | 1493 (93.3) | 167 (91.2)a | 1290 (91.0)a |
| Improvement | 48 (3.0) | 12 (6.6)a | 125 (8.8)a |
Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; CR, creatinine.
a
P < .05 compared with non-Aidi group.
b
P < .05 compared with Aidi group with less than conventional dosage.