Fig. 7.
The expression of tumorigenesis-related genes is enhanced during competitive interaction. (A,B) Diagrams showing how indicated differentially labeled CYAP and CVector cell populations were isolated for RNA-seq analysis. (C) Comparison of gene expression in CYAP and CVector cells isolated from spheroids cultured without competition (Non-comp.) as indicated in A. (D) Cellular functions were predicted to be activated (z-score≥2) or inactivated (z-score≤−2) in CYAP cells by Ingenuity Pathway Analysis of genes as shown in C. (E) Comparison of gene expression in CVector cells isolated from spheroids with competition (Comp.) or without competition as indicated in A and B. (F) Cellular functions were predicted to be activated (z-score≥1) or inactivated (z-score≤−1) in CVector cells involved in competition by Ingenuity Pathway Analysis of genes as shown in E. (G) Comparison of gene expression in CYAP cells isolated from spheroids with competition or without competition as indicated in A and B. (H) Cellular functions were predicted to be activated (z-score≥1) in CVector cells involved in competition by Ingenuity Pathway Analysis of genes as shown in G.