Table 6.
Model modification/subgroup | Concordance index | 95% confidence interval |
---|---|---|
Training cohort | ||
The US, our nomogram | 0.60 | 0.59–0.61 |
The US, model based on both T and N stages | 0.56 | 0.56–0.57 |
Validation cohorts | ||
Belgium, our nomogram | 0.58 | 0.55–0.60 |
Belgium, model based on both T and N stages | 0.54 | 0.52–0.56 |
The Netherlands, our nomogram | 0.62 | 0.59–0.65 |
The Netherlands, model based on both T and N stages | 0.56 | 0.54–0.59 |
Slovenia, our nomogram | 0.58 | 0.51–0.65 |
Slovenia, model based on both T and N stages | 0.52 | 0.47–0.57 |
Norway, our nomogram | 0.63 | 0.55–0.71 |
Norway, model based on both T and N stages | 0.61 | 0.54–0.68 |
Sensitivity analyses for the training US cohort | ||
Replacement | ||
Age group in place of continuous age | 0.59 | 0.59–0.60 |
Metastatic lymph node number in place of N stage | 0.60 | 0.59–0.61 |
Lymph node ratio in place of N stage | 0.61 | 0.61–0.62 |
The 8th version of T stage in place of the original stage | 0.61 | 0.60–0.61 |
The 8th version of N stage in place of the original stage | 0.60 | 0.59–0.61 |
The 8th version of T & N stages in place of the original stages | 0.61 | 0.60–0.62 |
Addition | ||
Harvested lymph node added | 0.60 | 0.60–0.61 |
Tumor size added | 0.61 | 0.60–0.61 |
Harvested lymph node & tumor size added | 0.61 | 0.60–0.62 |
Subgroup | ||
Diagnosis after 2009 | 0.60 | 0.59–0.61 |
White ethnicity | 0.60 | 0.59–0.61 |
Pancreas head | 0.60 | 0.59–0.61 |
Pancreas body & tail | 0.61 | 0.59–0.63 |
Concordance indexes in sensitivity analyses greater than that for the overall nomogram in the US are highlighted in italics