Table 2.
The effect of PLX5622 drug treatment on PrPSc deposition in 79A scrapie-infected retinal inner segment, as detected by anti-PrP (D13) antibody staining
| Time (dpi) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 67 | 82 | 104 | 118 | 129/131 | 134 | 144 | 153 | 159/163 | |
| No Drug | 0,0a | 1,1 | 2,2 | 2,2 | 3,3 | na | D,3 | D,D | D,D |
| PLX5622b | na | na | 2,2 | 2,2 | 3,3,3,D,D | D | na | na | na |
dpi Days post inoculation, na Not available
aEach number represents mean PrPSc score of two sections from one mouse. Entire retinal sections were scored for PrPSc present in the IS, as follows; 0 = No staining visible in the inner segment over entire retinal section; 1 = Low: less than 50 scattered deposits; 2 = Medium: more than 50 deposits; 3 = High: staining confluent along entire section; D, degenerated inner and outer segment, so assessment of staining not possible
bPLX5622 drug treatment was initiated at 90dpi, thus mice were not available at 67, 82 dpi. Last PLX5622-treated animal was euthanized at 134dpi