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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct 8;1864(6):819–826. doi: 10.1016/j.bbalip.2018.10.001

Figure 1.

Figure 1.

Illustration of Pla2g5 expression and function during allergen-induced pulmonary inflammation.

Dendritic cells (DCs) expressing Pla2g5 uptake and process allergens for presentation to T-cells in lymph nodes (LN). Activated T-cells are recruited to the lung by Pla2g5-expressing macrophages producing CCL22.

Epithelial cells release IL-33, which activates ILC2s and macrophages. Activated macrophages expressing Pla2g5 produce IL-33 and the FFAs, LA and OA, which further activate ILC2s to produce IL-5 for eosinophil recruitment and activation.