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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov 5;1864(6):846–860. doi: 10.1016/j.bbalip.2018.10.010

Figure 3. Participation of iPLA2β-derived lipids in metabolic and inflammatory processes.

Figure 3.

Activation of iPLA2β leads to the release of the sn-2 fatty acid and and production of a lysophospholipid. The free fatty acids and LPC have been linked to metabolic disorders including cardiac abnormalities associated with diabetes, hepatic steatosis, foam cell formation, and insulin resistance. Further, arachidonic acid and 12/15-LOX- and COX-derived metabolites of arachidonic acid, along with PAF and LPA, have been implicated in several inflammatory processes.