Table 3.
Nutritional characteristics in patients according to baseline nutritional status and BMI.
| Baseline nutritional status (PG-SGA) | Baseline BMI, kg/m2 | |||
|---|---|---|---|---|
| Characteristics | Well-nourished | Malnourished | < 25 | ≥25 |
| Number of patients, (%) | 37 (64) | 21 (36) | 33 (57) | 25 (43) |
| Weight loss, kg | ||||
| 6 mo pre-treatment | 0.6 (−2 – 1) | 6.3 (−6 – −1) | 4.5 (0.1–7) | 0.7 (0–4) |
| During treatment | 5.5 (−11 – −5) | 3.2 (−8–−1) | 3.2 (1–5) | 7.1 (5–9) |
| Differencea | 5.1 (4.0, 6.2) | 4.3 (2.7, 5.0) | 3.5 (4.9, 2.1) | 6.6 (8.2, 4.9) |
| p-value | 0.476 | 0.021 | ||
| Weight | ||||
| Baseline | 79.7 (68–89) | 62.9 (53–76) | 63.8 (56–68) | 86.1 (82–93) |
| End | 73.3 (62–81) | 58.9 (53–70) | 58.2 (53–66) | 80.1 (74.86) |
| Differencea | 68.0 (67.0, 69.1) | 69.3 (67.9, 70.8) | 69.0 (67.6, 70.4) | 67.8 (66.1, 69.6) |
| p-value | 0.158 | 0.368 | ||
| BMI | ||||
| Baseline | 24.8 (23–28) | 21.8 (18–25) | 21.6 (19–23) | 27.4 (26–29) |
| End | 23.6 (21–26) | 20.3 (19.23) | 25.2 (24–26) | 25.2 (24–26) |
| Differencea | 22.6 (22.2, 22.9) | 23.0 (22.6, 23.5) | 23.0 (22.5, 23.4) | 22.5 (21.9, 23.0) |
| p-value | 0.144 | 0.269 | ||
| FFM, kg | ||||
| Baseline | 61.3 (54–68) | 47.2 (42–61) | 51.1 (44–58) | 66 (61–73) |
| End | 58.6 (50–64) | 47.4 (42–56) | 47.0 (43–55) | 64 (57–70) |
| Differencea | 55.0 (53.9, 56.1) | 55.7 (54.1, 57.2) | 18.1 (17.6, 18.5) | 18.6 (18.1, 19.1) |
| p-value | 0.459 | 0.202 | ||
| FFMI, kg/m2 | ||||
| Baseline | 19.9 (19–22) | 16.9 (14–20) | 16.9 (16–19) | 21.0 (20–23) |
| End | 19.3 (17–20) | 16.3 (16–18) | 16.2 (16–18) | 20.1 (19–22) |
| Differencea | 18.3 (17.9, 18.6) | 18.4 (17.9, 18.9) | 18.1 (17.6, 18.5) | 18.6 (18.0, 19.2) |
| p-value | 0.249 | 0.202 | ||
| HGS, kg | ||||
| Baseline | 39.3 (33–49) | 28.0 (22–37) | 31.3 (22–37) | 42.3 (38–53) |
| End | 38.0 (29–47) | 27.3 (20–31) | 28.0 (21–36) | 40.7 (31–49) |
| Differencea | 34.2 (32.8, 35.7) | 32.6 (30.6, 34.6) | 33.4 (31.7, 35.1) | 32.0 (32.0, 35.9) |
| p-value | 0.214 | 0.705 | ||
Data presented as median, IQ (interquartile) range. FFM, fat-free mass; FFMI, fat-free mass index; HGS, handgrip strength; PG-SGA, patient generated subjective global assessment; OS, overall survival; DFS, disease-free survival.
a
Baseline-adjusted mean difference (95% CI) at the end of treatment, where the baseline measurement is included as a continuous covariate (ANCOVA). Well-nourished patients are compared to malnourished patients and patients with BMI < 25 kg/m2 are compared to patients with BMI ≥ 25 kg/m2.