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. 2018 Dec 21;168(2):394–404. doi: 10.1093/toxsci/kfy303

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Figure 1. — Characterization of BCRP expression and activity in hBCRP- and mBcrp-transfected MDCK cells. A, Western blot of transfected and control MDCK cells analyzing BCRP/Bcrp protein expression (72 kDa). β-actin (42 kDa) was used as a loading control. B, Retention of H33342 (10 μM) in empty vector control and transfected MDCK cells. Ko143 (1 μM) was used as a pharmacological inhibitor of BCRP/Bcrp (n = 6). Asterisks (*) represent statistically significant differences (p < .05) compared with control/vehicle. Daggers (†) represent statistically significant differences (p < .05) compared with vehicle within treatment group. Data represent the mean ± SD.