Figure 3.

Basolateral-to-apical transport of zearalenone and Rhodamine 123 in MDCK cells in the presence of a MDR1 inhibitor. Control MDCK cells grown on transwell inserts were assessed for translocation of (A) the MDR1 substrate Rhodamine 123 (10 μM) and (B) zearalenone (50 μM) across cell monolayers for 2 h as described in the Materials and Methods. PSC833 (5 μM) was used as a pharmacological inhibitor of MDR1. Data represent the mean pmol detected in the receiver compartment ± SD (n = 3–4). Asterisks (*) represent statistically significant differences (p < .05) compared with control cells.