Figure 3.

Effects of DEHP and DiNP on fertility index. Adult female CD-1 mice were orally dosed for 10 days with either vehicle control (corn oil), DEHP (20 µg/kg/day–200 mg/kg/day), or DiNP (20 µg/kg/day – 200 mg/kg/day). Females were mated with untreated male mice for breeding trials immediately post-dosing (Panel A, n = 12–23 mice/group), 3 months post-dosing (Panel B, n = 11–22 mice/group), and 9 months post-dosing (Panel C, n = 10–22 mice/group). The fertility index was calculated by dividing the number of females who successfully achieved pregnancy by the number of females who presented with a copulatory plug and multiplying by 100. Data are represented as percentages. Statistically significant difference when compared with control (p ≤ .05) is denoted with an asterisk (*).