Table 1.

Effects of DEHP and DiNP on Body Weight and Organ Weights

Time Point	Treatment	Body Weight (g)	Ovary Weight (g)	Uterine Weight (g)	Liver Weight (g)
Immediately post-dosing	Control	24.17 ± 0.55	0.0088 ± 0.0003	0.1050 ± 0.0065	1.3223 ± 0.0399
	20 µg/kg/day DEHP	24.06 ± 0.64	0.0095 ± 0.0008	0.0871 ± 0.0101	1.2810 ± 0.0726
	200 µg/kg/day DEHP	24.38 ± 0.69	0.0082 ± 0.0007	0.0767 ± 0.0036*	1.2295 ± 0.0676
	20 mg/kg/day DEHP	23.67 ± 0.62	0.0082 ± 0.0007	0.0722 ± 0.0054*	1.2490 ± 0.0422
	200 mg/kg/day DEHP	23.63 ± 0.65	0.0084 ± 0.0003	0.0814 ± 0.0079^	1.3291 ± 0.0826
	20 µg/kg/day DiNP	24.63 ± 0.79	0.0082 ± 0.0014	0.1034 ± 0.0111	1.3205 ± 0.0376
	100 µg/kg/day DiNP	23.25 ± 0.46	0.0073 ± 0.0014	0.1050 ± 0.0072	1.2145 ± 0.0549
	20 mg/kg/day DiNP	23.02 ± 0.35	0.0088 ± 0.0003	0.0938 ± 0.0099	1.1924 ± 0.0160
	200 mg/kg/day DiNP	23.67 ± 0.51	0.0085 ± 0.0006	0.0920 ± 0.0052	1.3561 ± 0.0657
3 months post-dosing	Control	30.95 ± 0.48	0.0212 ± 0.0002	0.1228 ± 0.0086	1.4679 ± 0.0401
	20 µg/kg/day DEHP	31.47 ± 0.66	0.0241 ± 0.0020	0.1254 ± 0.0039	1.5827 ± 0.0514
	200 µg/kg/day DEHP	30.29 ± 0.62	0.0199 ± 0.0018	0.1363 ± 0.0129	1.3443 ± 0.0592
	20 mg/kg/day DEHP	31.82 ± 1.76	0.0183 ± 0.0007	0.1467 ± 0.0183	1.5889 ± 0.1343
	200 mg/kg/day DEHP	30.97 ± 1.37	0.0161 ± 0.0009	0.1383 ± 0.0195	1.4389 ± 0.1071
	20 µg/kg/day DiNP	31.09 ± 0.68	0.0199 ± 0.0016	0.1207 ± 0.0092	1.3353 ± 0.0368
	100 µg/kg/day DiNP	30.75 ± 1.42	0.0215 ± 0.0023	0.1534 ± 0.0141	1.3968 ± 0.0615
	20 mg/kg/day DiNP	32.56 ± 0.97	0.0218 ± 0.0022	0.1512 ± 0.0317	1.5541 ± 0.0564
	200 mg/kg/day DiNP	30.06 ± 0.79	0.0210 ± 0.0017	0.1492 ± 0.0185	1.3395 ± 0.0299
9 months post-dosing	Control	48.78 ± 1.71	0.0290 ± 0.0004	0.2102 ± 0.0202	2.0953 ± 0.0656
	20 µg/kg/day DEHP	42.38 ± 2.07	0.0280 ± 0.0044	0.1818 ± 0.0142	1.8339 ± 0.1252
	200 µg/kg/day DEHP	44.50 ± 3.11	0.0244 ± 0.0042	0.2083 ± 0.0317	1.8429 ± 0.1250
	20 mg/kg/day DEHP	48.07 ± 2.99	0.0277 ± 0.0043	0.1663 ± 0.0165	2.0197 ± 0.0931
	200 mg/kg/day DEHP	44.78 ± 2.80	0.0224 ± 0.0038	0.2068 ± 0.0256	1.9930 ± 0.0844
	20 µg/kg/day DiNP	45.63 ± 3.36	0.0294 ± 0.0027	0.2036 ± 0.0382	1.7889 ± 0.0613
	100 µg/kg/day DiNP	46.14 ± 3.81	0.0343 ± 0.0091	0.2190 ± 0.0385	1.9513 ± 0.0497
	20 mg/kg/day DiNP	45.86 ± 5.14	0.0197 ± 0.0020	0.1759 ± 0.0234	2.0728 ± 0.2606
	200 mg/kg/day DiNP	47.75 ± 4.93	0.0236 ± 0.0048	0.2060 ± 0.0406	1.8549 ± 0.1936

Adult female CD-1 mice were orally dosed for 10 days with either vehicle control (corn oil), DEHP (20 µg/kg/day–200 mg/kg/day), or DiNP (20 µg/kg/day–200 mg/kg/day). Females were euthanized in diestrus either immediately post-dosing (n = 6–12 mice/group), 3 months post-dosing (n = 5–12 mice/group), or 9 months post-dosing (n = 4–12 mice/group) and body weight and organ weights were measured. Data are represented as means ± SE. Statistically significant difference when compared with control (p ≤ .05) is denoted with an asterisk (*). Borderline statistical significance (.05 < p ≤ .10) is denoted with a caret (^).