Table 3.
Sitagliptin (N = 93) | Vildagliptin (N = 94) | Saxagliptin (N = 90) | P* value | |
---|---|---|---|---|
BMI (kg/m2) change | −0.5 ± 1.9 | −0.1 ± 0.7 | 0.3 ± 0.8 | 0.41 |
TC (mmol/L) change | 0.1 (−0.4 to 0.4) | −0.1 (−0.5 to 0.5) | 0.5 (0.2–1.0) | 0.01 |
LDL-C (mmol/L) change | −0.2 ± 0.8 | −0.2 ± 1.1 | 0.3 ± 1.1 | 0.05 |
HDL-C (mmol/L) change | −0.00 ± 0.2 | 0.06 ± 0.4 | 0.02 ± 1.6 | 0.99 |
ALT (IU/L) change | 0.5 (−1.0 to 5.0) | 0.65 (−7.3 to 4.4) | 6.0 (0.0–20.2) | 0.08 |
AST (IU/L) change | 1.0 (−2.0 to 5.0) | −2.6 (−8.1 to 1.1) | 1.5 (−1.0 to 6.2) | 0.42 |
Cr (µmol/L) change | −1.1 ± 9.4 | 2.3 ± 11.7 | −2.8 ± 8.0 | 0.70 |
BIL (µmol/L) change | 8.1 ± 34.0 | 1.2 ± 6.7 | 0.9 ± 5.7 | 0.42 |
WBC (109/L) change | −0.2 ± 2.0 | −0.3 ± 2.1 | 0.05 ± 2.1 | 0.62 |
P value was calculated for Chi-square test across the three groups. P < 0.05 was considered to be statistically significant.
*Age and HbA1c-adjusted P value.
BMI, body mass index; FPG, fasting plasma glucose; HbA1c, hemoglobin A1c; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Cr, creatine; BIL, total bilirubin; WBC, white blood cell.