Table 5.
Indices | Region | Population | Model | Effect size | Heterogeneity | Egger’s regression intercept | Publication bias | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Z | P-value | D | 95% CI | I2 | P-value | T | P-value | |||||
Gray matter | Frontal | HC | Random | −2.008 | 0.045 | −0.740 | −1.463~–0.018 | 89.022 | 0.000 | 15.644 | 0.004 | Yes |
SZ | Fixed | 3.445 | 0.001 | 0.778 | 0.336~1.221 | 60.166 | 0.057 | 1.185 | 0.358 | No | ||
Temporal | HC | Fixed | −6.099 | 0.000 | −0.958 | −1.266~–0.650 | 17.898 | 0.301 | 2.967 | 0.097 | No | |
SZ | Random | 2.140 | 0.032 | 0.302 | 0.025~0.579 | 89.678 | 0.000 | 0.120 | 0.916 | No | ||
Parietal | SZ | Fixed | 5.346 | 0.000 | 1.124 | 0.712~1.537 | 0.000 | 0.923 | – | – | – | |
Occipital | HC | Fixed | −3.106 | 0.002 | −0.631 | −1.030~–0.233 | 33.581 | 0.220 | – | – | – | |
SZ | Fixed | 3.605 | 0.000 | 0.748 | 0.342~1.155 | 54.182 | 0.140 | – | – | – | ||
Limbic system | HC | Random | −1.485 | 0.138 | −0.900 | −2.087~0.288 | 93.838 | 0.000 | 11.921 | 0.053 | No | |
SZ | Fixed | 4.765 | 0.000 | 0.939 | 0.553~1.325 | 0.000 | 0.631 | – | – | – | ||
Basal nuclei | SZ | Fixed | 4.689 | 0.000 | 0.952 | 0.554~1.350 | 0.000 | 0.869 | – | – | – | |
White matter | All | HC | Random | 0.081 | 0.936 | 0.018 | −0.430~0.467 | 80.609 | 0.000 | 1.325 | 0.256 | No |
SZ | Random | −0.295 | 0.768 | −0.087 | −0.667~0.492 | 79.300 | 0.008 | 4.468 | 0.140 | No |
Abbreviations: CMA, Comprehensive Meta-Analysis; HC, healty control; SZ, schizophrenia.