Table 4. Top 10 compounds predicted to have activity against liver fibrosis as predicted via connectivity map.
| ID | Median_ Score | Name | Description | Target |
|---|---|---|---|---|
| BRD-K99029477 | −93.11 | Prometon | Photosynthesis inhibitor | |
| BRD-K19554809 | −88.43 | MK-212 | Serotonin receptor agonist | HTR2A, HTR2Ba, HTR2C |
| BRD-A68631409 | −85.73 | Evodiamine | ATPase inhibitor, TRPV agonist | TRPV1 |
| BRD-K70557564 | −85.48 | Zosuquidar | P glycoprotein inhibitor, P glycoprotein modulator | ABCB1a, ABCB4 |
| BRD-A61858259 | −83.89 | CAY-10415 | Insulin sensitizer | INS |
| BRD-K09900591 | −81.7 | Caffeic-acid | Lipoxygenase inhibitor, HIV integrase inhibitor, NFkB pathway inhibitor, nitric oxide production inhibitor, PPAR receptor modulator, tumor necrosis factor production inhibitor | ALOX5a, MIF, RELA, TNF |
| BRD-A82238138 | −81.69 | Budesonide | Glucocorticoid receptor agonist, glucocordicoid receptor antagonist, immunosuppressant | NR3C1 |
| BRD-K52080565 | −80.2 | Rilmenidine | Adrenergic receptor agonist, imidazoline receptor agonist | NISCH |
| BRD-K66175015 | −75.46 | Afatinib | EGFR inhibitor, receptor tyrosine protein kinase inhibitor, tyrosine kinase inhibitor | EGFR, ERBB2, ERBB4 |
| BRD-K82357231 | −74.73 | Desloratadine | Histamine receptor antagonist | HRH1 |
Notes.
a
Targets were matched to DEGs in selected datasets.