Table 2 –

Multivariable Regression coefficients for Measures of Sarcopenia used continuously (ALM and ALM:BMI)

	ALM					ALM:BMI
	Model 1		Model 2		Ix	Model 1		Model 2		Ix
Variable	β ± se	p	β ± se	p		β ± se	p	β ± se	p	p
Non-Fasting
Systolic	−0.224±0.091	0.18	−0.209±0.09	0.03	0.008	−14.1±3.895	0.001	−14.22±3.92	0.001	0.13
Diastolic	0.053±0.078	0.83	0.140±0.076	0.07	0.47	5.57±2.81	0.053	3.42±2.77	0.22	0.85
Cholesterol
Total	−0.644±0.209	0.001	−0.462±0.229	0.05	0.002	−7.35±9.17	0.43	−10.47±9.00	0.25	0.36
HDL-C	−1.056±0.079	0.85	−0.979±0.083	<0.001	<0.001	8.24±2.69	0.004	5.75±2.63	0.03	0.07
Triglycerides	3.462±0.469	0.79	2.70±0.489	<0.001	<0.001	−81.7±13.6	<0.001	−62.45±14.93	<0.001	0.02
ln triglycerides	0.0231±0.003	0.29	0.0192±0.003	<0.001	<0.001	−0.575±0.083	<0.001	−0.48±0.089	<0.001	0.001
Glucose	0.965±0.199	.018	0.292±0.165	0.08	<0.001	−30.0±7.83	<0.001	−15.39±6.62	0.03	0.22
Inflammatory
C-reactive protein	−0.0028±0.005	<0.001	−0.0044±0.0051	0.39	0.05	−0.897±0.150	<0.001	−0.881±0.153	<0.001	0.007
ln CRP	0.0287±0.006	0.001	0.027±0.006	<0.001	0.62	−2.58±0.26	<0.001	−2.57±0.272	<0.001	0.03
Fibrinogen	0.519±0.486	<0.001	0.108±0.475	0.82	0.14	−124.2±22.1	<0.001	−117.03±22.2	<0.001	0.004
Fasting Variables
HOMA-IR	0.359±0.057	0.002	0.305±0.055	<0.001	<0.001	−6.63±1.99	0.002	−6.22±1.73	0.001	0.001
HOMA-B	7.15±1.28	0.73	7.58±1.42	<0.001	0.07	−34.5±88.6	0.70	−36.68±84.73	0.67	0.03
Triglycerides	2.81±1.03	0.74	2.343±0.97	0.02	0.009	−60.4±18.2	0.002	−55.62±17.4	0.003	0.003
Ln trig	0.0171±0.006	0.86	0.0147±0.006	0.02	0.03	−0.38±0.096	<0.001	−0.355±0.093	0.001	0.002
Insulin	1.064±0.167	<0.001	0.963±2.06	0.001	<0.001	−22.2±6.14	0.001	−21.3±5.60	0.001	0.001
LDL-Cholesterol	−0.063±0.393	0.12	0.112±0.402	0.78	0.38	−3.77±13.9	0.79	−5.03±13.07	0.70	0.91

All values represented are from multivariable linear regression models (β coefficient ± standard error) with p-values.

Values bolded are considered statistically significant

Model 1: adjusted for age, sex race, education, smoking status, arthritis

Model 2: Model 1 co-variates, cancer and diabetes

Interaction (Ix): interaction term obesity (Body Fat) term x ASM with model 1 co-variates

Abbreviations: ALM: Appendicular lean mass; BMI: body mass index; HDL-C: high density lipoprotein cholesterol; HOMA: homeostatic assessment model; IR: insulin resistance; Ix: interaction; LDL-C: low density lipoprotein cholesterol; S-sensitivity; s.e.: standard error.

Natural log transformation was used for triglycerides and C-reactive protein