Appendix Table 3A –
Multivariable Regression coefficients for ALM-defined Sarcopenia (high/low)
| ALM Sarcopenia Present/Absent | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
| β ± se | p | β ± se | p | β ± se | p | β ± se | p | |
| Non-Fasting | ||||||||
| Systolic | 1.74±1.08 | 0.12 | 2.15±1.10 | 0.06 | 2.36±1.11 | 0.04 | 2.13±1.09 | 0.06 |
| Diastolic | 0.00003±0.705 | 1.00 | 0.233±0.70 | 0.74 | −0.0078±0.046 | 0.87 | −0.084±0.68 | 0.90 |
| Cholesterol | ||||||||
| Total | 3.82±2.23 | 0.09 | 4.02±2.35 | 0.09 | 4.75±2.63 | 0.08 | 3.11±2.41 | 0.20 |
| HDL-C | 7.16±0.83 | <0.001 | 7.93±0.81 | <0.001 | 7.04±0.80 | <0.001 | 7.56±0.79 | <0.001 |
| Triglycerides | −21.0±3.51 | <0.001 | −23.6±3.55 | <0.001 | −19.8±3.89 | <0.001 | −20.69±3.29 | <0.001 |
| Ln triglycerides | −0.13±0.021 | <0.001 | −0.151±0.022 | <0.001 | −0.118±0.023 | <0.001 | −0.135±0.02 | <0.001 |
| Glucose | −5.43±1.55 | 0.001 | −5.09±1.71 | 0.005 | −3.66±1.79 | 0.05 | −2.34±1.41 | 0.10 |
| Inflammatory | ||||||||
| C-reactive protein | 0.014±0.04 | 0.72 | 0.027±0.04 | 0.50 | 0.065±0.04 | 0.11 | 0.033±0.04 | 0.41 |
| Ln crp | −0.154±0.045 | 0.001 | −0.14±0.044 | 0.003 | 0.0057±0.046 | 0.90 | −0.126±0.04 | 0.007 |
| Fibrinogen | −0.164±4.26 | 0.97 | −0.238±4.31 | 0.96 | 6.70±4.57 | 0.15 | 1.62±4.37 | 0.71 |
| Fasting Variables | ||||||||
| HOMA-IR | −1.63±0.27 | <0.001 | −1.64±0.25 | <0.001 | −1.19±0.27 | <0.001 | −1.43±0.23 | <0.001 |
| HOMA-B | −23.2±5.57 | <0.001 | −20.3±6.84 | 0.006 | −11.8±5.68 | 0.05 | −21.3±6.04 | 0.001 |
| Triglycerides | −15.0±6.9 | 0.04 | −20.9±6.54 | 0.003 | −17.2±6.4 | 0.01 | −19.3±6.14 | 0.004 |
| Ln trig | −0.079±0.042 | 0.07 | −0.12±0.04 | 0.006 | 0.01±0.003 | 0.002 | −0.110±0.036 | 0.005 |
| Insulin | −4.65±0.72 | <0.001 | −4.83±0.67 | <0.001 | −3.27±0.67 | <0.001 | −4.41±0.59 | <0.001 |
| LDL-C | 0.43±3.07 | 0.89 | 0.75±3.28 | 0.82 | 2.46±3.34 | 0.47 | 0.407±3.25 | 0.90 |
Values bolded are considered statistically significant
Model 1: adjusted for age, sex race, education, smoking status, arthritis
Model 2: Model 1 co-variates, cancer and diabetes
Interaction (Ix): interaction term obesity (Body Fat) term x ASM with model 1 co-variates
Abbreviations: ALM: Appendicular lean mass; BMI: body mass index; HDL-C: high density lipoprotein cholesterol; HOMA: homeostatic assessment model; IR: insulin resistance; Ix: interaction; LDL-C: low density lipoprotein cholesterol; S-sensitivity; s.e.: standard error.
Natural log transformation was used for triglycerides and C-reactive protein