Appendix Table 3B –
Multivariable Regression coefficients for ALM:BMI defined Sarcopenia (high/low)
| ALM:BMI defined Sarcopenia Present/Absent | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
| β ± se | p | β ± se | p | β ± se | p | β ± se | p | |
| Non-Fasting | ||||||||
| Systolic | 2.13±0.90 | 0.023 | 2.01±0.95 | 0.04 | 1.97±0.97 | 0.05 | 1.90±0.98 | 0.06 |
| Diastolic | −0.38±0.63 | 0.55 | −0.32±0.64 | 0.62 | −0.373±0.73 | 0.61 | −0.059±0.65 | 0.93 |
| Cholesterol | ||||||||
| Total | 0.33±2.03 | 0.87 | 0.63±2.03 | 0.76 | −0.65±1.86 | 0.73 | 0.97±1.97 | 0.62 |
| HDL-C | −1.61±0.56 | 0.006 | −0.76±0.59 | 0.21 | 1.90±0.61 | 0.003 | −0.390±0.57 | 0.50 |
| Triglycerides | 13.2±3.53 | 0.001 | 9.75±3.53 | 0.008 | 0.50±3.41 | 0.89 | 6.91±3.73 | 0.07 |
| Ln triglycerides | 0.093±0.020 | <0.001 | 0.067±0.021 | 0.002 | −0.010±0.021 | 0.62 | 0.052±0.021 | 0.019 |
| Glucose | 6.12±1.51 | <0.001 | 6.05±1.57 | <0.001 | 3.59±1.74 | 0.05 | 4.00±1.31 | 0.004 |
| Inflammatory | ||||||||
| C-reactive protein | 0.15±0.04 | <0.001 | 0.161±0.04 | <0.001 | 0.105±0.045 | 0.02 | 0.16±0.04 | <0.001 |
| Ln crp | 0.392±0.053 | <0.001 | 0.409±0.053 | <0.001 | 0.128±0.05 | 0.01 | 0.403±0.054 | <0.001 |
| Fibrinogen | 20.7±4.65 | <0.001 | 21.9±4.80 | <0.001 | 10.8±4.8 | 0.03 | 20.7±4.74 | <0.001 |
| Fasting Variables | ||||||||
| HOMA-IR | 1.19±0.74 | 0.12 | 1.15±0.75 | 0.14 | 0.307±0.87 | 0.73 | 1.11±0.705 | 0.13 |
| HOMA-B | −2.05±16.6 | 0.90 | −2.33±16.9 | 0.89 | −21.6±15.7 | 0.18 | −2.47±16.4 | 0.88 |
| Triglycerides | 16.4±6.88 | 0.02 | 9.92±6.93 | 0.16 | 3.23±7.70 | 0.68 | 9.50±6.67 | 0.17 |
| Ln trig | 0.10±0.04 | 0.01 | 0.063±0.036 | 0.10 | 0.012±0.04 | 0.77 | 0.061±0.35 | 0.10 |
| Insulin | 2.94±1.88 | 0.13 | 2.80±1.89 | 0.15 | −0.26±2.05 | 0.90 | 2.68±1.77 | 0.14 |
| LDL-C | −1.14±2.82 | 0.69 | −0.88±2.97 | 0.77 | −4.010±3.22 | 0.21 | −1.17±2.70 | 0.67 |
Values bolded are considered statistically significant
Model 1: adjusted for age, sex race, education, smoking status, arthritis
Model 2: Model 1 co-variates, cancer and diabetes
Interaction (Ix): interaction term obesity (Body Fat) term x ASM with model 1 co-variates
Abbreviations: ALM: Appendicular lean mass; BMI: body mass index; HDL-C: high density lipoprotein cholesterol; HOMA: homeostatic assessment model; IR: insulin resistance; Ix: interaction; LDL-C: low density lipoprotein cholesterol; S-sensitivity; s.e.: standard error.
Natural log transformation was used for triglycerides and C-reactive protein