Appendix Table 4A:
Prevalence and Relationship of Sarcopenia and Sarcopenic Obesity by Quartile of Variable: ALM-definition
| ALM-defined Sarcopenia | ALM-defined Sarcopenic Obesity | ||||||
|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 1 | Model 3 | |||
| Variable & Quartile | Rate (%) | Odds Ratio [95%CI] | Odds Ratio [95%CI] | Odds Ratio [95%CI] | Rate (%) | Odds Ratio [95%CI] | Odds Ratio [95%CI] |
| C-reactive protein | p=0.02 | p=0.42 | |||||
| Low | 33.8 | referent | referent | referent | 25.5 | referent | referent |
| 25–50 | 26.8 | 0.64 [0.51,0.81] | 0.77 [0.62,0.98] | 0.65 [0.52,0.82] | 22.6 | 0.82 [0.65,1.04] | 0.83 [0.65,1.06] |
| 50–75 | 23.7 | 0.58 [0.45,0.74] | 0.75 [0.58,0.98] | 0.59 [0.46,0.76] | 23.6 | 0.80 [0.61,1.05] | 0.82 [0.63,1.08] |
| High | 31.7 | 0.79 [0.64,0.97] | 1.08 [0.87,1.35] | 0.81 [0.66,1.01] | 26.1 | 0.94 [0.74,1.21] | 0.99 [0.77,1.26] |
| Fibrinogen | p=0.21 | p=0.19 | |||||
| Low | 26.5 | referent | referent | referent | 21.3 | referent | referent |
| 25–50 | 28.6 | 1.00 [0.73,1.38] | 1.14 [0.84,1.56] | 1.03 [0.73,1.44] | 23.3 | 1.02 [0.72,1.45] | 1.06 [0.74,1.52] |
| 50–75 | 29.8 | 1.01 [0.75, 1.37] | 1.26 [0.95,1.68] | 1.04 [0.76,1.44] | 24.5 | 1.07 [0.78,1.46] | 1.09 [0.79,1.52] |
| High | 32.8 | 0.98 [0.71,1.34] | 1.23 [0.88,1.71] | 1.04 [0.75,1.43] | 26.3 | 1.01 [0.73,1.38] | 1.05 [0.76,1.45] |
| HOMA-IR | p<0.001 | p=0.003 | |||||
| Low | 50.4 | referent | referent | referent | 31.3 | referent | referent |
| 25–50 | 31.8 | 0.44 [0.31,0.63] | 0.55 [0.37,0.81] | 0.44 [0.31,0.62] | 27.1 | 0.85 [0.57,1.28] | 0.85 [0.57,1.27] |
| 50–75 | 27.7 | 0.35 [0.21,0.57] | 0.50 [0.29,0.84] | 0.34 [0.21,0.55] | 24.7 | 0.75 [0.44,1.28] | 0.74 [0.44,1.26] |
| High | 11.5 | 0.10 [0.05,0.21] | 0.14 [0.07,0.31] | 0.10 [0.05,0.19] | 11.1 | 0.27 [0.13,0.53] | 0.24 [0.12,0.49] |
| HOMA-B | P<0.001 | p=0.03 | |||||
| Low | 37.3 | referent | referent | referent | 22.8 | referent | referent |
| 25–50 | 37.2 | 0.98 [0.63,1.51] | 1.14 [0.73,1.79] | 0.88 [0.57,1.35] | 29.0 | 1.38 [0.90,2.11] | 1.36 [0.87,2.12] |
| 50–75 | 28.8 | 0.70 [0.42,1.16] | 0.95 [0.54,1.67] | 0.63 [0.36,1.08] | 25.4 | 1.23 [0.65,2.31] | 1.18 [0.61,2.29] |
| High | 18.3 | 0.35 [0.22,0.56] | 0.53 [0.33,0.87] | 0.32 [0.19,0.53] | 16.3 | 0.68 [0.35,1.33] | 0.66 [0.33,1.33] |
All values represented are odds ratios [95% confidence intervals).
Each variable (C-reactive protein, fibrinogen, HOMA-IR and HOMA-S) were stratified by quartile. Rate represents the proportion of individuals within the quartile (low, 25–50, 50–75, or high) that fulfill criteria for sarcopenia or sarcopenic obesity definitions. The primary outcome is presence/absence of sarcopenia or sarcopenic obesity and the primary predictor is quartile of the variable.
Model 1: age, sex, race, education, smoking, arthr
Model 2: Model 1 co-variates and body fat
Model 3: Model 1 co-variates with diabetes and cancer