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. Author manuscript; available in PMC: 2019 Mar 25.
Published in final edited form as: Nat Neurosci. 2018 Sep 24;21(10):1332–1340. doi: 10.1038/s41593-018-0235-9

Fig. 2 |. Conformational strains and their implications for the spectrum of synucleinopathies and tauopathies.

Fig. 2 |

Various NDs are associated with the accumulation of tau and α-Syn aggregates, which are referred as tauopathies and synucleinopathies. Recent evidence suggests that aggregates adopting different structures, illustrated here as schematics, may be responsible for these diseases.