Fig. 3 |. Cross-seeding interactions between diverse misfolded protein aggregates.

In vitro and in vivo experiments have shown that aggregates composed of one protein usually seed the aggregation of the same protein (homologous seeding). However, in some circumstances, an aggregate may also seed the aggregation of a different protein, in a process termed heterologous seeding or cross-seeding. Cross-seeding events may explain the frequent finding of mixed pathologies in which more than one misfolded protein aggregate is found in a patient brain.