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. Author manuscript; available in PMC: 2019 Mar 25.
Published in final edited form as: J Med Chem. 2017 Jun 27;60(13):5586–5598. doi: 10.1021/acs.jmedchem.7b00273

Figure 6.

Figure 6.

Compound 2 treatment resulted in apoptosis and vascular disruption of NCI-H460 xenograft tumors. Representative images of HE staining and IHC staining of CD31 (endothelial marker), cleaved caspase-3 (apoptosis marker), and Ki67 (proliferation marker) in different treatment groups. Sections were counterstained with hematoxylin. Red arrows in CD31 staining images indicate micro-vessels. Scale bar, 100 μm.