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. Author manuscript; available in PMC: 2019 Mar 25.
Published in final edited form as: J Med Chem. 2017 Jun 27;60(13):5586–5598. doi: 10.1021/acs.jmedchem.7b00273

Table 2.

Tumor Growth Inhibition of 2 on Human Lung H460 Xenograft Tumors in Nude Micea

body weight change
 antitumor activity
dose (mg/kg) animals start/end start (g) end (g) % tumor weight (g) inhibition rate (%)
vehicle 8/8 22.50 ± 1.23 26.40 ± 1.43 17.42  2.71 ± 1.07
2   0.25 8/8 22.44 ± 1.27 25.96 ± 1.54 15.71  2.23 ± 0.57 17.8
2   0.5 8/8 22.28 ± 1.33 23.85 ± 1.57  7.30  1.72 ± 0.78* 36.8
2   1.0 8/8 22.13 ± 1.24 20.50 ± 3.27 −7.23  1.03 ± 0.71*** 61.9
paclitaxel 15 8/8 22.50 ± 1.29 23.59 ± 2.66  4.99  1.08 ± 0.78** 60.4
a

Administration by iv. Schedule: Q5D × 4, that is, every 5 days for 3 weeks. Data are presented as the mean ± SD

*

p < 0.05

**

p < 0.01

***

p < 0.001 vs control.