Table 3.

General linear models for the association of DRB1 tag haplotypes as explanatory variables with type 2 diabetes mellitus, AIR, 30 min insulin, body fat percentage and insulin sensitivity (M) as dependent variables

Dependent variable	n	Explanatory variable
		DRB1 *02	DRB1 *04	DRB1 *08	Age (years)	Sex (women)	Birth year	Body fat (%)	M	30 min glucose
Type 2 diabetes	2892	0.676a (0.001)	0.969a (0.408)	1.010a (0.473)	1.087 (<0.001)	1.225 (0.009)	1.004 (0.282)
Log acute insulin response	236	1.300b (0.010)	0.989b (0.458)	1.062b (0.328)	0.986 (0.018)	0.798 (0.006)		1.014 (0.016)	0.386 (0.002)
Log 30 min insulin	236	1.202c (0.014)	0.897c (0.124)	1.099c (0.250)	0.984 (0.001)	0.811 (0.005)		1.021 (<0.001)	0.290 (<0.001)	1.007 (<0.001)
Body fat percentage	236	1.967d (0.056)	−0.924d (0.194)	0.936d (0.244)	0.090 (0.089)	11.166 (<0.001)
Log insulin sensitivity	236	1.054e (0.115)	1.000e (0.490)	1.114e (0.047)	1.000 (0.371)	1.138 (<0.001)		0.948 (<0.001)

Each model was adjusted for the genetic correlation within sibships (p values are in parentheses)

For log-transformed variables the effect measure represents the antilog of the β coefficient

^aOdds ratio for diabetes in persons with presence compared with absence of the DRB1 allele

^bRatio of AIR in persons with presence compared with absence of the DRB1 allele

^cRatio of 30 min insulin concentration in persons with presence compared with absence of the DRB1 allele

^dDifference in mean body fat percentage between persons with presence or absence of the DRB1 allele

^eRatio of insulin sensitivity (M) in persons with presence compared with absence of the DRB1 allele. The model included an additional covariate, body fat percentage squared, with estimate 1.000 and p=0.008