Table 4.

Reduced general linear models for the association of HLA-DRB1*02 by tag SNP rs9268852*A

Dependent variable	n	Explanatory variable
		DRB1 *02	Age (years)	Sex (women)	Birth year	Body fat (%)	Insulin sensitivity	30 min glucose
Type 2 diabetes	3265	0.723a (0.002)	1.092 (<0.001)	1.292 (<0.001)	1.012 (0.030)
Log acute insulin response	266	1.306b (0.005)	0.993 (0.074)	0.807 (0.005)		1.014 (0.006)	0.446 (0.002)
Log 30 min insulin	266	1.178c (0.017)	0.993 (0.004)	0.818 (0.005)		1.021 (<0.001)	0.299 (<0.001)	1.007 (<0.001)
Body fat percentage	266	2.505d (0.010)	0.052 (0.121)	10.817 (<0.001)
Log insulin sensitivity	266	1.023e (0.277)	1.000 (0.372)	1.132 (<0.001)		0.940 (<0.001)

Each model was adjusted for the genetic correlation within sibships (p values are in parentheses)

For log-transformed variables the effect measure represents the antilog of the β coefficient

^aOdds ratio for diabetes in persons with presence compared with absence of the DRB1 allele

^bRatio of AIR in persons with presence compared with absence of the DRB1 allele

^cRatio of 30 min insulin concentration in persons with presence compared with absence of the DRB1 allele

^dDifference in mean body fat percentage between persons with presence or absence of the DRB1 allele

^eRatio of insulin sensitivity (M) in persons with presence compared with absence of the DRB1 allele. The model included an additional covariate, body fat percentage squared, with estimate 1.000 and p=0.001