This data, from 2869 patients across 78 studies, shows increases in both responder rate and seizure freedom rate over time. At last follow-up 60% of patients achieved responder status to VNS and 8% of patients were seizure free. N = 650, 405, 1503, 876, and 326 patients at each follow-up period, respectively. VNS, vagus nerve stimulation. (From Englot DJ, Rolston JD, Wright CW, et al. Rates and predictors of seizure freedom with vagus nerve stimulation for intractable epilepsy. Neurosurgery. 2015;79(3):345–353; with permission.)