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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Crit Care Med. 2019 Apr;47(4):e301–e309. doi: 10.1097/CCM.0000000000003638

Figure 1.

Figure 1.

Schematic of pharmacokinetics of morphine and its metabolites. CL is clearance with the respective routes of elimination. V is the volume of the respective compartments. Q is the intercompartmental clearance. Morphine clearance and metabolite formation is CL10 + CL13 + CL14. Morphine metabolite clearances are defined as CL30 and CL40.