Table 3. Demographics and clinical characteristics of 243 pneumonia patients requiring mechanical ventilation, from whom Escherichia coli was isolated, France, 2012–2014* .
| Characteristic | Value |
|---|---|
| Age, y, median (IQR) |
64 (52–73) |
| Sex | |
| M | 183 (75.3) |
| F |
60 (24.7) |
| SAPS II at admission, median (IQR) |
57 (42–69) |
| Comorbid conditions | |
| Chronic alcohol consumption | 56 (23) |
| Diabetes mellitus | 45 (18.5) |
| Neoplastic disease | 43 (17.7) |
| Immunosuppression† | 77 (31.7) |
| Cirrhosis | 12 (4.9) |
| Chronic kidney disease | 18 (7.4) |
| Dialysis | 5 (2.1) |
| Chronic respiratory disease | 33 (13.6) |
| Chronic heart failure |
43 (17.7) |
| Reason for ICU admission | |
| Acute respiratory failure | 61 (25.1) |
| Coma | 48 (19.8) |
| Septic shock | 44 (18.1) |
| Cardiac arrest | 28 (11.5) |
| Cardiogenic shock | 14 (5.8) |
| Polytrauma | 22 (9.1) |
| Postoperative care | 8 (3.3) |
| Hemorrhagic shock |
5 (2.1) |
| Exposure to antimicrobial drug therapy in previous 3 mo | 98 (40.3) |
| Amoxicillin | 6 (2.5) |
| Amoxicillin/clavulanic acid | 38 (15.6) |
| Third-generation cephalosporin | 19 (7.8) |
| Aminoglycosides | 29 (11.9) |
| Piperacillin/tazobactam | 24 (9.9) |
| Quinolone | 10 (4.1) |
| Carbapenem |
11 (4.5) |
| Polymicrobial sampling | 57 (23.5) |
| ICU length of stay, d (IQR) | 17 (7–33) |
| Hospital length of stay, d (IQR) |
24 (10–45) |
| Death | |
| While in ICU | 90 (37) |
| While in hospital | 99 (40.7) |
| Associated with E. coli | 27 (11.1) |
*Values are no. (%) except as indicated. ICU, intensive care unit; IQR, interquartile range; SAPS II, Simplified Acute Physiology Score II. †Defined by >1 immunosuppression factor among neoplastic disease, hematologic malignancy, HIV infection, immunosuppressive therapy, corticosteroids therapy.