Figure 7.

Dominant mouse and human PE-III epitopes are well-predicted by a structure-based epitope prediction algorithm. A, prediction of mouse PE-III epitopes using structure-based processing likelihood (15), MHC-binding prediction for the I-A^d MHCII molecule, and their combination. B, prediction of human PE-III epitopes using structure-based processing likelihood, MHC-binding prediction, and their combination. Vertical lines indicate positions of experimentally mapped epitopes. Bottom tic marks represent 20 residue peptides detailed in Table S3.