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. 2019 Feb 8;294(12):4290–4303. doi: 10.1074/jbc.RA118.007008

Figure 3.

Figure 3.

Epitopes (d ≤ 4 Å) recognized by 3C11, AVFluIgG01, and 65C6 define an optimized VS1 on H5N1 globular head. A, the sequence alignment of AH05 (A/Anhui/1/2005) and HK97 (A/HongKong/156/1997) HA globular heads. The epitopes (d ≤ 4 Å) recognized by 3C11, AVFluIgG01, and 65C6 are marked with yellow, cyan, and green. B, surface representation illustrates the 3C11 epitope (in yellow), AVFluIgG01 epitope (in cyan), and 65C6 epitope (in green) on the globular head, whereas the VS1 previously defined is circled by a solid line. C, surface representation illustrates previous VS1 circled by a solid line and the extended VS1 circled by a dashed line and colored in orange. D, the sequence comparison of the optimized H5 VS1 with H1 Sa site and H3 Site A. The residues (Ala-242–Glu-246) are colored in orange and correspond to the orange patch of C.