Figure 6.

Different angles approaching the HA trimer of four VS1-specific antibodies. The complex structures of antibodies FLD194 (PDB code 5A3I), 65C6 (PDB code 5DUM), AVFluIgG01, and 3C11 are superimposed onto the A/Anhui/1/2005 HA trimer (PDB Code 4KWM) from the top view. HA1 is colored in green on one of three monomers and is in the same orientation in all panels. The RBS of the neighboring monomer is circled by a red dashed line. The Fabs of FLD194, 65C6, AVFluIgG01, and 3C11 are colored in purple, yellow, cyan, and pink, respectively. The long axes of the four Fabs are shown as red cylinders. The approaching angles of the antibodies are defined by the angle between the long axes of 65C6, AVFluIgG01, and 3C11 (red solid line) and the long axis of FLD194 (red dashed line), respectively.