Table 1.

Summary of known mechanisms of resistance to RET inhibition

Gene	Type of resistance mechanism	Evidence	References
RET	Different fusion partners with different drug sensitivity	Preclinical	37, 38, 40
		Clinical	23, 33
RET	Missense mutations	Preclinical	41
		Clinical	42
Genes of EGFR pathway (eg, ERK, AKT)	Increased expression	Preclinical	45, 46, 48
MDM2	Amplification	Clinical	47

Abbreviations: EGFR, epidermal growth factor receptor; RET, REarranged during Transfection.