Table 1.
Gene | Type of resistance mechanism | Evidence | References |
---|---|---|---|
RET | Different fusion partners with different drug sensitivity | Preclinical | 37, 38, 40 |
Clinical | 23, 33 | ||
RET | Missense mutations | Preclinical | 41 |
Clinical | 42 | ||
Genes of EGFR pathway (eg, ERK, AKT) | Increased expression | Preclinical | 45, 46, 48 |
MDM2 | Amplification | Clinical | 47 |
Abbreviations: EGFR, epidermal growth factor receptor; RET, REarranged during Transfection.