TABLE E5.
OTUs positively associated with sphingolipid metabolite module eigenvalues and with food sensitization compared with food allergy
Association with sphingolipid module |
Association with food allergy (vs food sensitization) |
Association with food sensitization (vs control) |
Association with food allergy (vs control) |
Association with Cesarean section (vs vaginal delivery) |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|
OTU ID | Taxa | Log2 fold change |
PBH
value |
Log2 fold change |
P
value |
Log2 fold change |
P
value |
Log2
fold change |
P
value |
Log2 fold change |
P
value |
577170 | Bacteroides unidentified species | 10.1 | .002 | −3.6 | .01 | 1.2 | .27 | −1.9 | .20 | −2.7 | .06 |
184753 | Bacteroides unidentified species | 9.2 | .01 | −5.2 | <.001 | 0.7 | .49 | −2.8 | .07 | −4.5 | .002 |
3472078 | Bacteroides unidentified species | 8.9 | .01 | −3.3 | .04 | 1.9 | .09 | −1.4 | .36 | −1.7 | .31 |
182157 | Bacteroides unidentified species | 7.8 | .02 | −2.9 | .03 | 1.1 | .27 | −1.6 | .23 | −2.9 | .02 |
188735 | Bacteroides unidentified species | 7.5 | .02 | −3.3 | .04 | 0.7 | .55 | −2.4 | .12 | −2.2 | .19 |
4354042 | Bacteroides unidentified species | 7.1 | .03 | −3.4 | .03 | 0.5 | .65 | −1.9 | .23 | −4.4 | .01 |
Negative binomial regression models of food allergy or sensitization phenotype were adjusted for age; models of mode of delivery were adjusted for age, sex, race/ethnicity, study center, maternal education, breast-feeding, and solid foods status.
P values denoting significant associations are in boldface. P values for associations with the sphingolipid module are adjusted for 420 comparisons (microbiome-wide analysis).